Antiviral drug Triazavirin, selectively labeled with 2H, 13C, and 15N stable isotopes. Synthesis and properties

被引：0
|
作者：
Tatyana S. Shestakova
Sergey L. Deev
Igor А. Khalymbadzha
Vladimir L. Rusinov
Alexander S. Paramonov
Alexander S. Arseniev
Zakhar O. Shenkarev
Valery N. Charushin
Oleg N. Chupakhin
机构：
[1] Ural Federal University named after the first President of Russia B. N. Yeltsin,Postovsky Institute of Organic Synthesis
[2] Ural Branch of the Russian Academy of Sciences,Shemyakin
[3] Russian Academy of Sciences,Ovchinnikov Institute of Bioorganic Chemistry
来源：
Chemistry of Heterocyclic Compounds | 2021年 / 57卷
关键词：
azoloazines; antiviral activity; NMR spectroscopy; spin-spin coupling constants; stable isotopes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Isotope-labeled antiviral drug Triazavirin containing 2H, 13C, and 15N atoms in its structure has been synthesized. 13C2H3I and KS13CN served as donors of 13C isotopes. The use of 13С-MeI containing 2H atoms made it possible to additionally incorporate deuterium labels into the structure of the compound. The 15N atoms were incorporated using 15N-enriched sodium nitrite, aminoguanidine carbonate, and ethyl nitroacetate. The resulting 2H3,13C2,15N3-Triazavirin was characterized by NMR spectroscopy.
引用
下载
收藏
页码：479 / 482
页数：3
相关论文
共 50 条
  • [1] Antiviral drug Triazavirin, selectively labeled with 2H, 13C, and 15N stable isotopes. Synthesis and properties
    Shestakova, Tatyana S.
    Deev, Sergey L.
    Khalymbadzha, Igor A.
    Rusinov, Vladimir L.
    Paramonov, Alexander S.
    Arseniev, Alexander S.
    Shenkarev, Zakhar O.
    Charushin, Valery N.
    Chupakhin, Oleg N.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2021, 57 (04) : 479 - 482
  • [2] Analog of antiviral drug Triazavirin (Riamilovir) labeled with stable isotopes 13C and 15N. Synthesis and NMR characteristics
    Shestakova, T. S.
    Deev, S. L.
    Eltsov, O. S.
    Khalymbadzha, I. A.
    Shevyrin, V. A.
    Rusinov, V. L.
    Charushin, V. N.
    Chupakhin, O. N.
    RUSSIAN CHEMICAL BULLETIN, 2024, 73 (02) : 372 - 378
  • [3] Synthesis of the [2H,15N]-labeled antiviral drug “triazavirine”
    T. S. Shestakova
    I. A. Khalymbadzha
    S. L. Deev
    O. S. Eltsov
    V. L. Rusinov
    Z. O. Shenkarev
    A. S. Arseniev
    O. N. Chupakhin
    Russian Chemical Bulletin, 2011, 60 : 729 - 732
  • [4] Synthesis of the [2H,15N]-labeled antiviral drug "triazavirine"
    Shestakova, T. S.
    Khalymbadzha, I. A.
    Deev, S. L.
    Eltsov, O. S.
    Rusinov, V. L.
    Shenkarev, Z. O.
    Arseniev, A. S.
    Chupakhin, O. N.
    RUSSIAN CHEMICAL BULLETIN, 2011, 60 (04) : 729 - 732
  • [5] Synthesis of 15N and 13C selectively labeled anandamide
    Xie, XQ
    Yang, HQ
    Choi, G
    Lin, SY
    Makriyannis, A
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2002, 45 (09): : 775 - 784
  • [6] NMR assignment of polymerase β labeled with 2H, 13C, and 15N in complex with substrate DNA
    Mueller, Geoffrey A.
    DeRose, Eugene F.
    Kirby, Thomas W.
    London, Robert E.
    BIOMOLECULAR NMR ASSIGNMENTS, 2007, 1 (01) : 33 - 35
  • [7] NMR assignment of polymerase β labeled with 2H, 13C, and 15N in complex with substrate DNA
    Geoffrey A. Mueller
    Eugene F. DeRose
    Thomas W. Kirby
    Robert E. London
    Biomolecular NMR Assignments, 2007, 1 : 33 - 35
  • [8] Synthesis of stable-isotope (13C and 15N) labeled nucleosides and their applications
    Kawashima, E
    Kamaike, K
    MINI-REVIEWS IN ORGANIC CHEMISTRY, 2004, 1 (03) : 309 - 332
  • [9] Chemical synthesis of 13C and 15N labeled nucleosides
    Lagoja, IM
    Herdewijn, P
    SYNTHESIS-STUTTGART, 2002, (03): : 301 - 314
  • [10] Precursor discrimination of designer drug benzylpiperazine using δ13C and δ15N stable isotopes
    Beckett, Nicola M.
    Grice, Darren I.
    Carter, James F.
    Cresswell, Sarah L.
    SCIENCE & JUSTICE, 2015, 55 (01) : 57 - 62
12345