Synthesis of the [2H,15N]-labeled antiviral drug "triazavirine"

被引:11
|
作者
Shestakova, T. S. [1 ]
Khalymbadzha, I. A. [1 ]
Deev, S. L. [1 ]
Eltsov, O. S. [1 ]
Rusinov, V. L. [1 ,2 ]
Shenkarev, Z. O. [3 ]
Arseniev, A. S. [3 ]
Chupakhin, O. N. [1 ,2 ]
机构
[1] Ural Fed Univ, Ekaterinburg 620002, Russia
[2] Russian Acad Sci, I Ya Postovsky Inst Organ Synth, Ural Branch, Ekaterinburg 620041, Russia
[3] Russian Acad Sci, MM Shemyakin & Yu A Ovchinnikov Inst Bioorgan Che, Moscow 117997, Russia
基金
俄罗斯基础研究基金会;
关键词
diazonium salt; azocoupling; H-2; N-15]-labeled; triazavirine; NMR spectra; PHARMACOKINETICS; ISOTOPE;
D O I
10.1007/s11172-011-0113-z
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Selective methods for the incorporation of stable isotopes N-15 and H-2 into the structure of antiviral medicine "triazavirine" 1 were developed. The synthesized isotopically modified "triazavirine" 1-H-2(3),N-15(3) contained the labeled atoms in both the azole and the azine rings. C-13 and N-15 NMR spectra of the isotope-containing sample 1-H-2(3),N-15(3) were thoroughly analyzed.
引用
收藏
页码:729 / 732
页数:4
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