Antiviral drug Triazavirin, selectively labeled with 2H, 13C, and 15N stable isotopes. Synthesis and properties

被引：0

作者：

Tatyana S. Shestakova

Sergey L. Deev

Igor А. Khalymbadzha

Vladimir L. Rusinov

Alexander S. Paramonov

Alexander S. Arseniev

Zakhar O. Shenkarev

Valery N. Charushin

Oleg N. Chupakhin

机构：

[1] Ural Federal University named after the first President of Russia B. N. Yeltsin,Postovsky Institute of Organic Synthesis

[2] Ural Branch of the Russian Academy of Sciences,Shemyakin

[3] Russian Academy of Sciences,Ovchinnikov Institute of Bioorganic Chemistry

来源：

Chemistry of Heterocyclic Compounds | 2021年 / 57卷

关键词：

azoloazines; antiviral activity; NMR spectroscopy; spin-spin coupling constants; stable isotopes;

D O I：

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中图分类号：

学科分类号：

摘要：

Isotope-labeled antiviral drug Triazavirin containing 2H, 13C, and 15N atoms in its structure has been synthesized. 13C2H3I and KS13CN served as donors of 13C isotopes. The use of 13С-MeI containing 2H atoms made it possible to additionally incorporate deuterium labels into the structure of the compound. The 15N atoms were incorporated using 15N-enriched sodium nitrite, aminoguanidine carbonate, and ethyl nitroacetate. The resulting 2H3,13C2,15N3-Triazavirin was characterized by NMR spectroscopy.

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页码：479 / 482

页数：3

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