Antiviral drug Triazavirin, selectively labeled with 2H, 13C, and 15N stable isotopes. Synthesis and properties

被引：0
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作者：
Tatyana S. Shestakova
Sergey L. Deev
Igor А. Khalymbadzha
Vladimir L. Rusinov
Alexander S. Paramonov
Alexander S. Arseniev
Zakhar O. Shenkarev
Valery N. Charushin
Oleg N. Chupakhin
机构：
[1] Ural Federal University named after the first President of Russia B. N. Yeltsin,Postovsky Institute of Organic Synthesis
[2] Ural Branch of the Russian Academy of Sciences,Shemyakin
[3] Russian Academy of Sciences,Ovchinnikov Institute of Bioorganic Chemistry
来源：
Chemistry of Heterocyclic Compounds | 2021年 / 57卷
关键词：
azoloazines; antiviral activity; NMR spectroscopy; spin-spin coupling constants; stable isotopes;
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摘要：
Isotope-labeled antiviral drug Triazavirin containing 2H, 13C, and 15N atoms in its structure has been synthesized. 13C2H3I and KS13CN served as donors of 13C isotopes. The use of 13С-MeI containing 2H atoms made it possible to additionally incorporate deuterium labels into the structure of the compound. The 15N atoms were incorporated using 15N-enriched sodium nitrite, aminoguanidine carbonate, and ethyl nitroacetate. The resulting 2H3,13C2,15N3-Triazavirin was characterized by NMR spectroscopy.
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页码：479 / 482
页数：3
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