Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration

被引:0
|
作者
Michael Lattke
Stephanie N. Reichel
Alexander Magnutzki
Alireza Abaei
Volker Rasche
Paul Walther
Dinis P. Calado
Boris Ferger
Thomas Wirth
Bernd Baumann
机构
[1] Ulm University,Institute of Physiological Chemistry
[2] Ulm University,Core Facility Small Animal MRI
[3] Ulm University,Central Facility for Electron Microscopy
[4] The Francis Crick Institute,Immunity and Cancer Laboratory
[5] Boehringer Ingelheim Pharma GmbH & Co. KG,CNS Diseases Research
[6] The Francis Crick Institute,Neural Stem Cell Biology Laboratory
关键词
NF-kappaB; IKK; Neuroinflammation; Cerebellar ataxia; Purkinje cell degeneration; Bergmann glia; Glutamate transporter; EAAT; Excitotoxicity;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [31] The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms
    Balbinot, Camille
    Armant, Olivier
    Elarouci, Nabila
    Marisa, Laetitia
    Martin, Elisabeth
    De Clara, Etienne
    Onea, Alina
    Deschamps, Jacqueline
    Beck, Felix
    Freund, Jean-Noel
    Duluc, Isabelle
    JOURNAL OF EXPERIMENTAL MEDICINE, 2018, 215 (03): : 911 - 926
  • [32] Expression of cell cycle regulator cdk2ap1 suppresses tumor cell phenotype by non-cell-autonomous mechanisms
    Zolochevska, Olga
    Figueiredo, Marxa L.
    ORAL ONCOLOGY, 2009, 45 (09) : E106 - E112
  • [33] IFNγ triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cell-autonomous effects of mutant SOD1
    Aebischer, J.
    Cassina, P.
    Otsmane, B.
    Moumen, A.
    Seilhean, D.
    Meininger, V.
    Barbeito, L.
    Pettmann, B.
    Raoul, C.
    CELL DEATH AND DIFFERENTIATION, 2011, 18 (05): : 754 - 768
  • [34] Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis
    Mei Zhou
    Hong Yang
    R. Marc Learned
    Hui Tian
    Lei Ling
    Nature Communications, 8
  • [35] IFNγ triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cell-autonomous effects of mutant SOD1
    J Aebischer
    P Cassina
    B Otsmane
    A Moumen
    D Seilhean
    V Meininger
    L Barbeito
    B Pettmann
    C Raoul
    Cell Death & Differentiation, 2011, 18 : 754 - 768
  • [36] Cell-Autonomous and Non-Cell-Autonomous Regulation of a Feeding State-Dependent Chemoreceptor Gene via MEF-2 and bHLH Transcription Factors
    Gruner, Matthew
    Grubbs, Jeremy
    McDonagh, Aja
    Valdes, Dominic
    Winbush, Ari
    van der Linden, Alexander M.
    PLOS GENETICS, 2016, 12 (08):
  • [37] Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis
    Zhou, Mei
    Yang, Hong
    Learned, R. Marc
    Tian, Hui
    Ling, Lei
    NATURE COMMUNICATIONS, 2017, 8
  • [38] Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling
    Rojas, Fabiola
    Gonzalez, David
    Cortes, Nicole
    Ampuero, Estibaliz
    Hernandez, Diego E.
    Fritz, Elsa
    Abarzua, Sebastian
    Martinez, Alexis
    Elorza, Alvaro A.
    Alvarez, Alejandra
    Court, Felipe
    van Zundert, Brigitte
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2015, 9
  • [39] T cell-specific targeting of IKK2 impairs T cell receptor induced activation of NF-κB and promotes cardiac allograft survival.
    Wang, T
    Schmidt-Supprian, MC
    Ge, GS
    Hancock, AS
    Han, RW
    Rajewsky, KJ
    Hancock, WW
    AMERICAN JOURNAL OF TRANSPLANTATION, 2005, 5 : 417 - 417
  • [40] Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells
    Marchetto, Maria C. N.
    Muotri, Alysson R.
    Mu, Yangling
    Smith, Alan M.
    Cezar, Galbriela G.
    Gage, Fred H.
    CELL STEM CELL, 2008, 3 (06) : 649 - 657