A three-dimensional human neural cell culture model of Alzheimer’s disease

被引：0

作者：

Se Hoon Choi

Young Hye Kim

Matthias Hebisch

Christopher Sliwinski

Seungkyu Lee

Carla D’Avanzo

Hechao Chen

Basavaraj Hooli

Caroline Asselin

Julien Muffat

Justin B. Klee

Can Zhang

Brian J. Wainger

Michael Peitz

Dora M. Kovacs

Clifford J. Woolf

Steven L. Wagner

Rudolph E. Tanzi

Doo Yeon Kim

机构：

[1] Genetics and Aging Research Unit,Division of Mass Spectrometry Research

[2] MassGeneral Institute for Neurodegenerative Disease,Department of Neurosciences

[3] Massachusetts General Hospital,undefined

[4] Harvard Medical School,undefined

[5] Korea Basic Science Institute,undefined

[6] Cheongju-si,undefined

[7] Chungbuk 363-883,undefined

[8] South Korea,undefined

[9] Institute of Reconstructive Neurobiology,undefined

[10] Life and Brain Center,undefined

[11] University of Bonn and Hertie Foundation,undefined

[12] 53127 Bonn,undefined

[13] Germany,undefined

[14] FM Kirby Neurobiology Center,undefined

[15] Boston Children’s Hospital and Harvard Stem Cell Institute,undefined

[16] The Whitehead Institute for Biomedical Research,undefined

[17] University of California,undefined

[18] San Diego,undefined

[19] La Jolla,undefined

[20] California 92093,undefined

[21] USA,undefined

来源：

Nature | 2014年 / 515卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Early-onset familial Alzheimer’s disease mutations induce both amyloid-β and tau pathologies in differentiated human neural stem cells in 3D cultures.

引用

页码：274 / 278

页数：4

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