A 3D human neural cell culture system for modeling Alzheimer's disease

被引：0
|
作者：
Young Hye Kim
Se Hoon Choi
Carla D'Avanzo
Matthias Hebisch
Christopher Sliwinski
Enjana Bylykbashi
Kevin J Washicosky
Justin B Klee
Oliver Brüstle
Rudolph E Tanzi
Doo Yeon Kim
机构：
[1] Genetics and Aging Research Unit,
[2] MassGeneral Institute for Neurodegenerative Disease,undefined
[3] Massachusetts General Hospital,undefined
[4] Harvard Medical School,undefined
[5] Biomedical Omics Group,undefined
[6] Korea Basic Science Institute,undefined
[7] Cheongju-si,undefined
[8] Chungbuk,undefined
[9] Republic of Korea.,undefined
[10] Institute of Reconstructive Neurobiology,undefined
[11] Life and Brain Center,undefined
[12] University of Bonn and Hertie Foundation,undefined
来源：
Nature Protocols | 2015年 / 10卷
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学科分类号：
摘要：
Human neural progenitor cells with familial Alzheimer's disease mutations are differentiated in a 3D Matrigel matrix, leading to the extracellular aggregation of amyloid-β peptides and accumulation of hyperphosphorylated and aggregated tau protein.
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页码：985 / 1006
页数：21
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