A suPAR circulating factor causes kidney disease

被引：0
|
作者：
Stuart J Shankland
Martin R Pollak
机构：
[1] University of Washington,Stuart J. Shankland is in the Division of Nephrology
[2] Seattle,Martin R. Pollak is in the Division of Nephrology
[3] Washington,undefined
[4] USA.,undefined
[5] Beth Israel Deaconess Medical Center and Harvard Medical School,undefined
[6] Boston,undefined
[7] Massachusetts,undefined
[8] USA.,undefined
来源：
Nature Medicine | 2011年 / 17卷
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摘要：
For many years, investigators have been searching for an elusive circulating factor that could cause the common kidney disease focal segmental glomerulosclerosis (FSGS). The finding that a circulating, soluble form of the urokinase receptor (suPAR) can activate podocyte β3 integrin, leading to FSGS pathology (pages 952–960), provides new insights into this disease and may have important clinical implications.
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页码：926 / 927
页数：1
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