A suPAR circulating factor causes kidney disease

被引：0

作者：

Stuart J Shankland

Martin R Pollak

机构：

[1] University of Washington,Stuart J. Shankland is in the Division of Nephrology

[2] Seattle,Martin R. Pollak is in the Division of Nephrology

[3] Washington,undefined

[4] USA.,undefined

[5] Beth Israel Deaconess Medical Center and Harvard Medical School,undefined

[6] Boston,undefined

[7] Massachusetts,undefined

[8] USA.,undefined

来源：

Nature Medicine | 2011年 / 17卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

For many years, investigators have been searching for an elusive circulating factor that could cause the common kidney disease focal segmental glomerulosclerosis (FSGS). The finding that a circulating, soluble form of the urokinase receptor (suPAR) can activate podocyte β3 integrin, leading to FSGS pathology (pages 952–960), provides new insights into this disease and may have important clinical implications.

引用

页码：926 / 927

页数：1

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