SuPAR, an emerging biomarker in kidney and inflammatory diseases

被引：46

作者：

Hamie, Lamiaa ^{[1
]}

Daoud, Georges ^{[1
]}

Nemer, Georges ^{[2
]}

Nammour, Tarek ^{[3
]}

El Chediak, Alissar ^{[3
]}

Uthman, Imad W. ^{[3
]}

Kibbi, Abdul Ghani ^{[4
]}

Eid, Assaad ^{[1
]}

Kurban, Mazen ^{[2
,4
]}

机构：

[1] Amer Univ Beirut, Dept Anat Cell Biol & Physiol Sci, Fac Med, Beirut, Lebanon

[2] Amer Univ Beirut, Dept Biochem & Mol Genet, Fac Med, Beirut, Lebanon

[3] Amer Univ Beirut, Med Ctr, Dept Internal Med, Beirut, Lebanon

[4] Amer Univ Beirut, Med Ctr, Dept Dermatol, Beirut, Lebanon

来源：

POSTGRADUATE MEDICAL JOURNAL | 2018年 / 94卷 / 1115期

关键词：

biomarker; diagnosis; inflammation; prognosis; screen; soluble urokinase plasminogen activator receptor; PLASMINOGEN-ACTIVATOR RECEPTOR; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; SOLUBLE UROKINASE RECEPTOR; ACUTE-PANCREATITIS; CIRCULATING SUPAR; RESPONSE SYNDROME; DIAGNOSTIC-VALUE; SERUM-LEVELS; PREDICTION; SEVERITY;

D O I：

10.1136/postgradmedj-2018-135839

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Soluble urokinase plasminogen activator receptor (suPAR) is a circulating form of a physiological and pathophysiological important cell surface receptor, implicated in inflammation. Recent studies showed that suPAR is a promising biomarker, useful for diagnosis, assessment and prognosis of several diseases. This review summarises the majority of preliminary studies and analyses the significance and the clinical application of suPAR in various clinical conditions. SuPAR seems to have a significant value in the diagnosis as well as prognosis of many diseases; nonetheless, it merits large-scale studies to set cut-off values that help physicians in following up their patients and accordingly tailor their treatment plans.

引用

页码：517 / 524

页数：8

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