Glycotoxins in the diet promote diabetes and diabetic complications

被引：60
|
作者：
Vlassara H. [1 ]
Striker G. [1 ]
机构：
[1] Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10029, One Gustave Levy Place
来源：
Current Diabetes Reports | 2007年 / 7卷 / 3期
关键词：
Diabetic Complication; Aldose Reductase; Methylglyoxal; Benfotiamine; Dietary AGEs;
D O I：
10.1007/s11892-007-0037-z
中图分类号：
学科分类号：
摘要：
Oxidant stress underlines diabetes and diabetic complications, including cardiovascular, renal, and retinal disease. Advanced glycation and products (AGEs), or glycotoxins, are a significant contributor to oxidant stress in diabetes. The diet is a major, unrecognized source of AGEs. Importantly, reduction of dietary AGEs decreases circulating inflammatory markers in both diabetic patients and prediabetic patients complications in animal models. This beneficial outcome requires only a 50% decrease in dietary AGEs, making this necessary intervention practical and inexpensive. Copyright © 2007 by Current Medicine Group LLC.
引用
收藏
页码：235 / 241
页数：6
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