Advanced Glycation Endproducts in Diabetes and Diabetic Complications

被引：127
|
作者：
Vlassara, Helen [1 ]
Striker, Gary E. [2 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Geriatr & Med, Div Expt Diabet & Aging, New York, NY 10029 USA
[2] Icahn Sch Med Mt Sinai, Dept Geriatr & Med, Div Nephrol Expt Diabet & Aging, New York, NY 10029 USA
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2013年 / 42卷 / 04期
关键词：
Advanced glycation endproduct; Diabetes; Metabolism; Insulin resistance; LOW-DENSITY-LIPOPROTEIN; TNF RECEPTORS 1; END-PRODUCTS; OXIDATIVE-STRESS; ADVANCED GLYCOSYLATION; INSULIN-RESISTANCE; OXIDANT STRESS; DIETARY GLYCOTOXINS; AGE RECEPTOR-1; GLYOXALASE I;
D O I：
10.1016/j.ecl.2013.07.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This review presents insights from studies of advanced glycation end products (AGEs) in humans and mice. Although the emphasis is on the effects of exogenous AGEs and the suppression of specific host defense mechanisms, AGEs are also formed intradellularly, where they may contribute to several normal intracellular functions. It is only when the overall levels of AGEs in the extracellular and the intracellular spaces exceeds the ability of the native antioxidant (and AGE) defenses that they pose a problem.
引用
收藏
页码：697 / +
页数：24
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