Glycotoxins in the diet promote diabetes and diabetic complications

被引：60
|
作者：
Vlassara H. [1 ]
Striker G. [1 ]
机构：
[1] Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10029, One Gustave Levy Place
来源：
Current Diabetes Reports | 2007年 / 7卷 / 3期
关键词：
Diabetic Complication; Aldose Reductase; Methylglyoxal; Benfotiamine; Dietary AGEs;
D O I：
10.1007/s11892-007-0037-z
中图分类号：
学科分类号：
摘要：
Oxidant stress underlines diabetes and diabetic complications, including cardiovascular, renal, and retinal disease. Advanced glycation and products (AGEs), or glycotoxins, are a significant contributor to oxidant stress in diabetes. The diet is a major, unrecognized source of AGEs. Importantly, reduction of dietary AGEs decreases circulating inflammatory markers in both diabetic patients and prediabetic patients complications in animal models. This beneficial outcome requires only a 50% decrease in dietary AGEs, making this necessary intervention practical and inexpensive. Copyright © 2007 by Current Medicine Group LLC.
引用
收藏
页码：235 / 241
页数：6
相关论文
共 50 条
  • [31] From Diabetes to Diabetic Complications: Role of Autophagy
    Lin-hua Wang
    Yang-yang Wang
    Lian Liu
    Quan Gong
    Current Medical Science, 2023, 43 : 434 - 444
  • [32] Aminoacid Support in the Prevention of Diabetes and Diabetic Complications
    Anuradha, Carani Venkataraman
    CURRENT PROTEIN & PEPTIDE SCIENCE, 2009, 10 (01) : 8 - 17
  • [33] DIET IN MANAGEMENT OF DIABETES - DIABETIC PORTION SIZES
    HOSKING, M
    MEDICAL JOURNAL OF AUSTRALIA, 1976, 1 (22) : 843 - 844
  • [34] DIABETIC COMPLICATIONS WITHOUT MANIFEST DIABETES - COMPLICATIONS AS PRESENTING CLINICAL SYMPTOMS
    ELLENBERG, M
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1963, 183 (11): : 926 - &
  • [35] DIABETES-ASSOCIATED COMPLICATIONS AND TRADITIONAL INDIAN DIET
    RAHEJA, BS
    DIABETES CARE, 1987, 10 (03) : 382 - 383
  • [36] Glycotoxins in diet and tobacco smoking: The new faces of an old enemy, atherosclerosis
    Vlassara, H
    ATHEROSCLEROSIS, 1999, 144 : 171 - 171
  • [37] Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice
    Peppa, M
    Brem, H
    Ehrlich, P
    Zhang, JG
    Cai, WJ
    Li, Z
    Croitoru, A
    Thung, S
    Vlassara, H
    DIABETES, 2003, 52 (11) : 2805 - 2813
  • [38] The emerging roles of extracellular vesicles in diabetes and diabetic complications
    Zhou, Fan
    Huang, Liang
    Qu, Shun-Lin
    Chao, Ru
    Yang, Chen
    Jiang, Zhi-Sheng
    Zhang, Chi
    CLINICA CHIMICA ACTA, 2019, 497 : 130 - 136
  • [39] DIABETIC COMPLICATIONS OF NON-INSULIN-DEPENDENT DIABETES
    WATKINS, PJ
    GRENFELL, A
    EDMONDS, M
    DIABETIC MEDICINE, 1987, 4 (04) : 293 - 296
  • [40] Diabetic complications in patients with MODY3 diabetes
    Isomaa, H
    Henricsson, M
    Lehto, M
    Forsblom, C
    Hyrkko, A
    Sarelin, L
    Haggblom, M
    Groop, L
    DIABETOLOGIA, 1997, 40 : 635 - 635
12345