Synthesis, analgesic and antimicrobial activity of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates

被引：0
|
作者：
Yu. O. Sharavyeva
A. I. Siutkina
S. V. Chashchina
V. V. Novikova
R. R. Makhmudov
S. A. Shipilovskikh
机构：
[1] Perm State National Research University,Faculty of Physics and Technology
[2] Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation,undefined
[3] Federal Scientific Center of Medical and Preventive Health Risks Management Technologies,undefined
[4] National Research University ITMO,undefined
来源：
Russian Chemical Bulletin | 2022年 / 71卷
关键词：
analgesic activity; antimicrobial activity; Gewald thiophenes; 2,4-dioxobutanoic acids; 3-(thiophen-2-yl)imino-3; -furan-2-one;
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学科分类号：
摘要：
New substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates were obtained by the reaction of 2-((2-oxo-5-phenylfuran-3(2H)-ylidene)-amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile with alcohols. The structures of the compounds obtained were confirmed by 1H and 13C NMR spectroscopy and elemental analysis. A number of new compounds were found to have a pronounced analgesic activity, as well as a weak antimicrobial effect or its absence.
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页码：538 / 542
页数：4
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