Chemistry of iminofurans 3. *Synthesis and intramolecular cyclization of (Z)-4-aryl- 2-[3-(ethoxycarbonyl)-4,5,6,7-tetra- hydrobenzo[b]thiophen-2-ylamino]- 4-oxobuten-2-oic acids

被引：0
|
作者：
S. A. Shipilovskikh
A. E. Rubtsov
V. V. Zalesov
机构：
[1] Perm State University,
来源：
Chemistry of Heterocyclic Compounds | 2009年 / 45卷
关键词：
amino acids; 4-aryl-2-hydroxy-4-oxobuten-2-oic acids; 3-imino-3H-furan-2-ones; Gewald thiophene; cyclization;
D O I：
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学科分类号：
摘要：
(Z)-4-Aryl-2-[3-(ethoxycarbonyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino]-4-oxobuten-2-oic acids, which exist in the enamino keto form in solutions, were synthesized by the action of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate on 4-aryl-2-hydroxy-4-oxobuten-2-oic acids. Under the influence of acetic anhydride the obtained acids undergo cyclization to ethyl 2-(5-aryl-2-oxofuran-3(2H)-ylideneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylates.
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页码：658 / 661
页数：3
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