Synthesis, intramolecular cyclization, and antinociceptive activity of 4-(het)aryl-2-{[4-(4-chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]amino}-4-oxobut-2-enoic acids

被引：0
|
作者：
I. A. Gorbunova
I. P. Nikonov
R. R. Makhmudov
D. A. Shipilovskikh
P. S. Silaichev
S. A. Shipilovskikh
机构：
[1] Perm State National Research University,School of Physics and Engineering
[2] Perm National Research Polytechnic University,undefined
[3] ITMO University,undefined
来源：
Russian Chemical Bulletin | 2023年 / 72卷
关键词：
Gewald thiophenes; 2,4-dioxobutanoic acids; 3-iminofuran-2-ones; antinociceptive activity; toxicity; medications;
D O I：
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学科分类号：
摘要：
Synthesis and intramolecular cyclization of the substituted 4-(het)aryl-2-{[4-(4-chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]amino}-4-oxobut-2-enoic acids were studied. It was found that the synthesized compounds underwent the intramolecular cyclization to give the substituted ethyl 4-(4-chlorophenyl)-2-{[2-oxofuran-3(2H)-ylidene]-amino}thiophene-3-carboxylates. Evaluation of the biological activity of the synthesized compounds showed that they have pronounced antinociceptive activity along with low toxicity.
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页码：2255 / 2262
页数：7
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