Synthesis, intramolecular cyclization, and antinociceptive activity of 4-(het)aryl-2-{[4-(4-chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]amino}-4-oxobut-2-enoic acids

被引：0

作者：

I. A. Gorbunova

I. P. Nikonov

R. R. Makhmudov

D. A. Shipilovskikh

P. S. Silaichev

S. A. Shipilovskikh

机构：

[1] Perm State National Research University,School of Physics and Engineering

[2] Perm National Research Polytechnic University,undefined

[3] ITMO University,undefined

来源：

Russian Chemical Bulletin | 2023年 / 72卷

关键词：

Gewald thiophenes; 2,4-dioxobutanoic acids; 3-iminofuran-2-ones; antinociceptive activity; toxicity; medications;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Synthesis and intramolecular cyclization of the substituted 4-(het)aryl-2-{[4-(4-chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]amino}-4-oxobut-2-enoic acids were studied. It was found that the synthesized compounds underwent the intramolecular cyclization to give the substituted ethyl 4-(4-chlorophenyl)-2-{[2-oxofuran-3(2H)-ylidene]-amino}thiophene-3-carboxylates. Evaluation of the biological activity of the synthesized compounds showed that they have pronounced antinociceptive activity along with low toxicity.

引用

页码：2255 / 2262

页数：7

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