Synthesis and Intramolecular Cyclization of Substituted 4-(Het)aryl-4-oxo-2-thienylaminobut-2-enoic Acids Containing Nitrile Group in the Thiophene Ring

被引：0

作者：

Gorbunova, I. A. ^{[1
]}

Shipilovskikh, D. A. ^{[2
]}

Rubtsov, A. E. ^{[1
]}

Shipilovskikh, S. A. ^{[1
,3
]}

机构：

[1] Perm State Univ, Perm 614990, Russia

[2] Perm Natl Res Polytech Univ, Perm 614990, Russia

[3] ITMO Univ, St Petersburg 197101, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2021年 / 91卷 / 09期

关键词：

Gewald thiophenes; 2; 4-dioxobutanoic acids; 3-(thiophen-2-yl)iminofuran-2(3H)-one; CAP-SNATCHING ENDONUCLEASE; IMINOFURANS; RECYCLIZATION; DIKETO ACIDS; ETHYL; DECYCLIZATION; CHEMISTRY; DERIVATIVES; INHIBITORS;

D O I：

10.1134/S1070363221090048

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for the synthesis of substituted 4-(het)aryl-4-oxo-2-thienylaminobut-2-enoic acids containing a nitrile substituent in the thiophene ring was proposed. Intramolecular cyclization of the obtained compounds in the presence of propionic anhydride leads to the formation of new substituted 3-thienylimino-3H-furan-2-ones.

引用

页码：1623 / 1628

页数：6

共 50 条

[1] Synthesis and Intramolecular Cyclization of Substituted 4-(Het)aryl-4-oxo-2-thienylaminobut-2-enoic Acids Containing Nitrile Group in the Thiophene Ring
I. A. Gorbunova
D. A. Shipilovskikh
A. E. Rubtsov
S. A. Shipilovskikh
Russian Journal of General Chemistry, 2021, 91 : 1623 - 1628
[2] Synthesis and Analgesic Activity of Substituted 4-(Het)aryl-4-oxo-2-thienylaminobut-2-enoic Acids
S. A. Shipilovskikh
R. R. Makhmudov
D. Yu. Lupach
P. T. Pavlov
E. V. Babushkina
A. E. Rubtsov
Pharmaceutical Chemistry Journal, 2013, 47 : 366 - 370
[3] SYNTHESIS AND ANALGESIC ACTIVITY OF SUBSTITUTED 4-(HET)ARYL-4-OXO-2-THIENYLAMINOBUT-2-ENOIC ACIDS
Shipilovskikh, S. A.
Makhmudov, R. R.
Lupach, D. Yu.
Pavlov, P. T.
Babushkina, E. V.
Rubtsov, A. E.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2013, 47 (07) : 366 - 370
[4] Synthesis and Antibacterial Activity of 4-Oxo-2-thienylaminobut-2-enoic Acids
Gorbunova, I. A.
Shadrin, V. M.
Pulina, N. A.
Novikova, V. V.
Dubrovina, S. S.
Shipilovskikh, D. A.
Shipilovskikh, S. A.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2023, 93 (01) : 8 - 15
[5] Synthesis and Antibacterial Activity of 4-Oxo-2-thienylaminobut-2-enoic Acids
I. A. Gorbunova
V. M. Shadrin
N. A. Pulina
V. V. Novikova
S. S. Dubrovina
D. A. Shipilovskikh
S. A. Shipilovskikh
Russian Journal of General Chemistry, 2023, 93 : 8 - 15
[6] Synthesis and Intramolecular Cyclization of N-Substituted 2-Amino-4-aryl-4-oxo-2-butenoic Acids
A. E. Rubtsov
V. V. Zalesov
Russian Journal of Organic Chemistry, 2003, 39 : 869 - 874
[7] Synthesis and intramolecular cyclization of N-substituted 2-amino-4-aryl-4-oxo-2-butenoic acids
Rubtsov, AE
Zalesov, VV
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2003, 39 (06) : 869 - 874
[8] Synthesis, intramolecular cyclization, and antinociceptive activity of 4-(het)aryl-2-{[4-(4-chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]amino}-4-oxobut-2-enoic acids
Gorbunova, I. A.
Nikonov, I. P.
Makhmudov, R. R.
Shipilovskikh, D. A.
Silaichev, P. S.
Shipilovskikh, S. A.
RUSSIAN CHEMICAL BULLETIN, 2023, 72 (09) : 2255 - 2262
[9] Synthesis, intramolecular cyclization, and antinociceptive activity of 4-(het)aryl-2-{[4-(4-chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]amino}-4-oxobut-2-enoic acids
I. A. Gorbunova
I. P. Nikonov
R. R. Makhmudov
D. A. Shipilovskikh
P. S. Silaichev
S. A. Shipilovskikh
Russian Chemical Bulletin, 2023, 72 : 2255 - 2262
[10] SYNTHESIS, INTRAMOLECULAR CYCLIZATION AND ANTINOCICEPTIVE ACTIVITY OF 4-(HET)ARYL-2-{[3-(ETHOXYCARBONYL)-4-(4-R-PHENYL)THIOPHEN-2-YL]AMINO}4-OXOBUT-2-ENOIC ACIDS
Nikonov, I. P.
Sharavyeva, Yu. O.
Makhmudov, R. R.
Shipilovskikh, D. A.
Gorbunova, I. A.
IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA I KHIMICHESKAYA TEKHNOLOGIYA, 2024, 67 (11): : 22 - 32

← 1 2 3 4 5 →