Synthesis and Intramolecular Cyclization of Substituted 4-(Het)aryl-4-oxo-2-thienylaminobut-2-enoic Acids Containing Nitrile Group in the Thiophene Ring

被引：0

作者：

Gorbunova, I. A. ^{[1
]}

Shipilovskikh, D. A. ^{[2
]}

Rubtsov, A. E. ^{[1
]}

Shipilovskikh, S. A. ^{[1
,3
]}

机构：

[1] Perm State Univ, Perm 614990, Russia

[2] Perm Natl Res Polytech Univ, Perm 614990, Russia

[3] ITMO Univ, St Petersburg 197101, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2021年 / 91卷 / 09期

关键词：

Gewald thiophenes; 2; 4-dioxobutanoic acids; 3-(thiophen-2-yl)iminofuran-2(3H)-one; CAP-SNATCHING ENDONUCLEASE; IMINOFURANS; RECYCLIZATION; DIKETO ACIDS; ETHYL; DECYCLIZATION; CHEMISTRY; DERIVATIVES; INHIBITORS;

D O I：

10.1134/S1070363221090048

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for the synthesis of substituted 4-(het)aryl-4-oxo-2-thienylaminobut-2-enoic acids containing a nitrile substituent in the thiophene ring was proposed. Intramolecular cyclization of the obtained compounds in the presence of propionic anhydride leads to the formation of new substituted 3-thienylimino-3H-furan-2-ones.

引用

页码：1623 / 1628

页数：6

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