Synthesis and Antibacterial Activity of 4-Oxo-2-thienylaminobut-2-enoic Acids

被引：16
|
作者：
Gorbunova, I. A. [1 ]
Shadrin, V. M. [2 ]
Pulina, N. A. [2 ]
Novikova, V. V. [2 ]
Dubrovina, S. S. [2 ]
Shipilovskikh, D. A. [3 ]
Shipilovskikh, S. A. [1 ,4 ]
机构：
[1] Perm State Natl Res Univ, Perm 614990, Russia
[2] Perm State Pharmaceut Acad, Minist Hlth Russia, Perm 614990, Russia
[3] Perm Natl Res Polytech Univ, Perm 614990, Russia
[4] ITMO Univ, St Petersburg 197101, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 01期
关键词：
Gewald thiophenes; 2; 4-dioxobutanoic acids; 3-iminofuran-2-ones; antibacterial activity; antifungal activity; ANTINOCICEPTIVE ACTIVITY; ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; ANALGESIC ACTIVITY; ARYLDIKETO ACIDS; 2-AMINOTHIOPHENE; DESIGN;
D O I：
10.1134/S1070363223010024
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The hydrolysis of substituted 3-(3-cyanothiophen-2-yl)imino-3H-furan-2-ones was studied. It was found that the reaction proceeds with the opening of the furan ring and the formation of the corresponding 4-oxo-2-(3-cyanothiophen-2-yl)aminobut-2-enoic acids. The antibacterial activity of the obtained compounds against Staphylococcus aureus, Escherichia coli and Candida albicans was studied.
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页码：8 / 15
页数：8
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