Synthesis and biological activity of substituted 4-aryl-2-methylenehydrazino-4-oxobut-2-enoic acids and their derivatives

被引：0
|
作者：
N. A. Pulina
V. V. Zalesov
O. A. Bystritskaya
A. E. Rubtsov
N. V. Kutkovaya
机构：
[1] Perm State Pharmaceutical Academy,
[2] Perm State University,undefined
[3] Biomed Research and Production Company,undefined
来源：
Pharmaceutical Chemistry Journal | 2009年 / 43卷
关键词：
derivatives of 2-methylenehydrazino-4-aryl-4-oxobut-2-enoic acids; synthesis; biological activity;
D O I：
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中图分类号：
学科分类号：
摘要：
Aseries of substituted 2-methylenehydrazino-4-aryl-4-oxobut-2-enoic acids and their anilides and esters were obtained using reactions of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids and their amides and esters with benzophenone hydrazone, benzyl monohydrazone, and triphenylphosphazines. The methyl ester of 2-(1,2-diphenyl-2-oxoethylidenehydrazino)-4-(4-chlorophenyl)-4-oxobut-2-enoic acid was also synthesized by decyclization of 3-(1,2-diphenyl-2-oxoethylidenehydrazino)-5-(4-chlorophenyl)-3H-furan-2-one using methanol. The synthesized compounds exhibit moderate anti-inflammatory, analgesic, and antimicrobial activity.
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页码：444 / 447
页数：3
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