Search of Antimicrobial Activity in a Series of Substituted 4-Aryl-4-oxo-2-tienilaminobut-2-enoic Acids

被引：8

作者：

Shipilovskikh, Sergei A. ^{[1
,2
]}

Makhmudov, R. R. ^{[1
]}

Balandina, S. Yu ^{[1
]}

Rubtsov, Aleksandr E. ^{[1
]}

机构：

[1] Perm State Univ, Dept Chem, Bukireva 15, Perm 614990, Russia

[2] Ural Fed Univ, Inst Chem Technol, Mira 19, Ekaterinburg 620002, Russia

来源：

MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2019) | 2020年 / 2280卷

基金：

俄罗斯基础研究基金会;

关键词：

ANALGESIC ACTIVITY; RIBONUCLEASE H; CHEMISTRY; INHIBITORS; ETHYL; PHARMACOPHORE; DECYCLIZATION;

D O I：

10.1063/5.0018494

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Studied the antimicrobial activity against the test cultures of microorganisms St. aureus ATCC 906 and E. coli ATCC 1257 defined by two-fold serial dilutions in a liquid growth medium in a series of substituted 4-aryl-4-oxo-2-tienilaminobut-2-enoic acid. Found that several of the test substances have pronounced antimicrobial activity, and some are at the level of the reference drug dioxidine. Also analyzed acute toxicity (LD50, mg/ml) in white mice (females) weighing 16-18 g. after a single intraperitoneal injection for all the compounds obtained and found that they are practically non-toxic 5 class of drugs.

引用

页数：5

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