Search of Antimicrobial Activity in a Series of Substituted 4-Aryl-4-oxo-2-tienilaminobut-2-enoic Acids

被引：8
|
作者：
Shipilovskikh, Sergei A. [1 ,2 ]
Makhmudov, R. R. [1 ]
Balandina, S. Yu [1 ]
Rubtsov, Aleksandr E. [1 ]
机构：
[1] Perm State Univ, Dept Chem, Bukireva 15, Perm 614990, Russia
[2] Ural Fed Univ, Inst Chem Technol, Mira 19, Ekaterinburg 620002, Russia
来源：
MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2019) | 2020年 / 2280卷
基金：
俄罗斯基础研究基金会;
关键词：
ANALGESIC ACTIVITY; RIBONUCLEASE H; CHEMISTRY; INHIBITORS; ETHYL; PHARMACOPHORE; DECYCLIZATION;
D O I：
10.1063/5.0018494
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Studied the antimicrobial activity against the test cultures of microorganisms St. aureus ATCC 906 and E. coli ATCC 1257 defined by two-fold serial dilutions in a liquid growth medium in a series of substituted 4-aryl-4-oxo-2-tienilaminobut-2-enoic acid. Found that several of the test substances have pronounced antimicrobial activity, and some are at the level of the reference drug dioxidine. Also analyzed acute toxicity (LD50, mg/ml) in white mice (females) weighing 16-18 g. after a single intraperitoneal injection for all the compounds obtained and found that they are practically non-toxic 5 class of drugs.
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页数：5
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