Synthesis, Antimicrobial Activity, and Behavioral Response Effects of N-Substituted 4-Aryl-2-Hydroxy-4-Oxobut-2-Enoic Acid Hydrazides and Their Metal Complexes

被引：0
|
作者：
N. A. Pulina
A. S. Kuznetsov
A. I. Krasnova
V. V. Novikova
机构：
[1] Perm State Pharmaceutical Academy,
[2] Ministry of Health of the Russian Federation,undefined
来源：
Pharmaceutical Chemistry Journal | 2019年 / 53卷
关键词：
-substituted 4-aryl-2-hydroxy-4-oxobut-2-enoic acid 2-oxoethylidenehydrazides; metal complexes; antimicrobial activity; behavioral response;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
N-Substituted 4-aryl-2-hydroxy-4-oxobut-2-enoic acid hydrazides and their complexes with Ni(II), Mn(II), Co(II), Cu(II), and Zn(II) were prepared. Their antimicrobial activity and behavioral response effects in mice were studied. Compounds with low acute toxicities and activities comparable to or exceeding those of the reference drugs were discovered.
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页码：220 / 224
页数：4
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