Synthesis, analgesic and antimicrobial activity of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates

被引：0

作者：

Yu. O. Sharavyeva

A. I. Siutkina

S. V. Chashchina

V. V. Novikova

R. R. Makhmudov

S. A. Shipilovskikh

机构：

[1] Perm State National Research University,Faculty of Physics and Technology

[2] Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation,undefined

[3] Federal Scientific Center of Medical and Preventive Health Risks Management Technologies,undefined

[4] National Research University ITMO,undefined

来源：

Russian Chemical Bulletin | 2022年 / 71卷

关键词：

analgesic activity; antimicrobial activity; Gewald thiophenes; 2,4-dioxobutanoic acids; 3-(thiophen-2-yl)imino-3; -furan-2-one;

D O I：

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中图分类号：

学科分类号：

摘要：

New substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates were obtained by the reaction of 2-((2-oxo-5-phenylfuran-3(2H)-ylidene)-amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile with alcohols. The structures of the compounds obtained were confirmed by 1H and 13C NMR spectroscopy and elemental analysis. A number of new compounds were found to have a pronounced analgesic activity, as well as a weak antimicrobial effect or its absence.

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页码：538 / 542

页数：4

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