Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration

被引:0
|
作者
Jui-Hsia Weng
Ming-Ren Liang
Chien-Han Chen
Sok-Keng Tong
Tzu-Chiao Huang
Sue-Ping Lee
Yet-Ran Chen
Chao-Tsen Chen
Bon-chu Chung
机构
[1] Institute of Biochemistry and Molecular Biology,Department of Chemistry
[2] National Yang-Ming University,undefined
[3] Institute of Molecular Biology,undefined
[4] Academia Sinica,undefined
[5] National Taiwan University,undefined
[6] Agricultural Biotechnology Research Center,undefined
[7] Academia Sinica,undefined
来源
Nature Chemical Biology | 2013年 / 9卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
The neurosteroid pregnenolone binds the microtubule plus-end tracking protein CLIP-170 to promote microtubule polymerization and cell migration.[graphic not available: see fulltext]
引用
收藏
页码:636 / 642
页数:6
相关论文
共 50 条
  • [21] CLIP-170 family members: A motor-driven ride to microtubule plus ends
    Maekawa, H
    Schiebel, E
    DEVELOPMENTAL CELL, 2004, 6 (06) : 746 - 748
  • [22] Microtubule plus-end tracking by CLIP-170 requires EB1
    Dixit, Ram
    Barnett, Brian
    Lazarus, Jacob E.
    Tokito, Mariko
    Goldman, Yale E.
    Holzbaur, Erika L. F.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (02) : 492 - 497
  • [23] Drosophila CLIP-190 and mammalian CLIP-170 display reduced microtubule plus end association in the nervous system
    Beaven, Robin
    Dzhindzhev, Nikola S.
    Qu, Yue
    Hahn, Ines
    Dajas-Bailador, Federico
    Ohkura, Hiroyuki
    Prokop, Andreas
    MOLECULAR BIOLOGY OF THE CELL, 2015, 26 (08) : 1491 - 1508
  • [24] Expression and analysis of peptides corresponding to the microtubule-binding motifs of CLIP-170 and cofactor B
    Kwon, U
    Goodson, HV
    MOLECULAR BIOLOGY OF THE CELL, 2000, 11 : 199A - 199A
  • [25] THE RELATED MICROTUBULE-BINDING PROTEINS CLIP-170 AND RESTIN ARE EXPRESSED IN A VARIETY OF CHICKEN TISSUES
    GRIPARIC, LG
    VOLOSKY, JM
    KELLER, TCS
    MOLECULAR BIOLOGY OF THE CELL, 1995, 6 : 1491 - 1491
  • [26] Interactions between CLIP-170, dynactin complex, and EB1 at microtubule plus ends
    Goodson, HV
    Schroer, TA
    Morrison, E
    Valetti, C
    Kreis, T
    MOLECULAR BIOLOGY OF THE CELL, 2000, 11 : 198A - 199A
  • [27] Characterization of conserved microtubule binding motifs from CLIP-170: A plus end targeting protein that enhances microtubule polymerization
    Folker, ES
    Kwon, U
    Goodson, HV
    MOLECULAR BIOLOGY OF THE CELL, 2001, 12 : 434A - 434A
  • [28] The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis
    Akhmanova, A
    Mausset-Bonnefont, AL
    van Cappellen, W
    Keijzer, N
    Hoogenraad, CC
    Stepanova, T
    Drabek, K
    van der Wees, J
    Mommaas, M
    Onderwater, J
    van der Meulen, H
    Tanenbaum, ME
    Medema, RH
    Hoogerbrugge, J
    Vreeburg, J
    Uringa, EJ
    Grootegoed, JA
    Grosveld, F
    Galjart, N
    GENES & DEVELOPMENT, 2005, 19 (20) : 2501 - 2515
  • [29] The role of clip-170 and dynein in the assembly of apico-basal microtubule arrays in polarized epithelial cells
    Goldspink, D. A.
    Bellett, G.
    James, C.
    Mogensen, M. M.
    JOURNAL OF ANATOMY, 2007, 210 (05) : 623 - 623
  • [30] Cooperative Stabilization of Microtubule Dynamics by EB1 and CLIP-170 Involves Displacement of Stably Bound Pi at Microtubule Ends
    Lopus, Manu
    Manatschal, Cristina
    Buey, Ruben M.
    Bjelic, Sasa
    Miller, Herbert P.
    Steinmetz, Michel O.
    Wilson, Leslie
    BIOCHEMISTRY, 2012, 51 (14) : 3021 - 3030