Potentiation of the antimalarial activity of atovaquone by doxycycline against Plasmodium falciparum in vitro

被引：0
|
作者：
Anthony E. T. Yeo
Michael D. Edstein
G. Dennis Shanks
Karl H. Rieckmann
机构：
[1] Army Malaria Research Unit,
[2] Liverpool Military Area,undefined
[3] NSW 2174,undefined
[4] Australia,undefined
[5] 1653 Botany Road,undefined
[6] Banksmeadow NSW 2019,undefined
[7] Australia,undefined
[8] US Army Medical Research Unit Kenya,undefined
[9] Unit 64109,undefined
[10] Box 401,undefined
[11] APO AE 09831-4109,undefined
[12] USA,undefined
来源：
Parasitology Research | 1997年 / 83卷
关键词：
Malaria; Minimum Inhibitory Concentration; Inhibitory Concentration; Plasmodium; Doxycycline;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The effect of doxycycline, obtained from human volunteers administered doxycycline, on the minimum inhibitory concentration (MIC) of atovaquone was determined against the K1 and FC27 isolates of Plasmodium falciparum in vitro. Doxycycline concentrations ranging from 0.10-1.18 μg/ml added to atovaquone produced MIC ratios [atovaquone + doxycycline/atovaquone alone] ranging from 0.38 to 0.70. These results suggest that the antimalarial activity of atovaquone is potentiated by doxycycline. Additionally, these drugs may be rational partners for the treatment and prophylaxis of falciparum malaria.
引用
收藏
页码：489 / 491
页数：2
相关论文
共 50 条
  • [1] Potentiation of the antimalarial activity of atovaquone by doxycycline against Plasmodium falciparum in vitro
    Yeo, AET
    Edstein, MD
    Shanks, GD
    Rieckmann, KH
    PARASITOLOGY RESEARCH, 1997, 83 (05) : 489 - 491
  • [2] In vitro Potentiation of Antimalarial Activities by Daphnetin Derivatives Against Plasmodium falciparum
    FANG HUANG*
    ≠Chinese National Center for Drug Screening
    BiomedicalandEnvironmentalSciences, 2006, (05) : 367 - 370
  • [3] In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum
    Huang, Fang
    Tang, Lin-Hua
    Yu, Lin-Qian
    Ni, Yi-Chang
    Wang, Qin-Mei
    Nan, Fa-Jun
    BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 2006, 19 (05) : 367 - 370
  • [4] In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum
    Khurshida Begum
    Hye-Sook Kim
    Veena Kumar
    Igor Stojiljkovic
    Yusuke Wataya
    Parasitology Research, 2003, 90 : 221 - 224
  • [5] In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum
    Begum, K
    Kim, HS
    Kumar, V
    Stojiljkovic, I
    Wataya, Y
    PARASITOLOGY RESEARCH, 2003, 90 (03) : 221 - 224
  • [6] Pharmacodynamic interaction between atovaquone and other antimalarial compounds against Plasmodium falciparum in vitro
    Luetgendorf, Carola
    Rojanawatsirivet, Chaiporn
    Wernsdorfer, Gunther
    Sirichaisinthop, Jeeraphat
    Kollaritsch, Herwig
    Wernsdorfer, Walther H.
    WIENER KLINISCHE WOCHENSCHRIFT, 2006, 118 (Suppl 3) : 70 - 76
  • [7] INTERACTIONS OF ATOVAQUONE WITH OTHER ANTIMALARIAL-DRUGS AGAINST PLASMODIUM-FALCIPARUM IN-VITRO
    CANFIELD, CJ
    PUDNEY, M
    GUTTERIDGE, WE
    EXPERIMENTAL PARASITOLOGY, 1995, 80 (03) : 373 - 381
  • [8] The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum
    Kesinee Chotivanich
    Mathirut Mungthin
    Ronnatrai Ruengweerayuth
    Rachanee Udomsangpetch
    Arjen M Dondorp
    Pratap Singhasivanon
    Sasithon Pukrittayakamee
    Nicholas J White
    Malaria Journal, 11
  • [9] The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum
    Chotivanich, Kesinee
    Mungthin, Mathirut
    Ruengweerayuth, Ronnatrai
    Udomsangpetch, Rachanee
    Dondorp, Arjen M.
    Singhasivanon, Pratap
    Pukrittayakamee, Sasithon
    White, Nicholas J.
    MALARIA JOURNAL, 2012, 11
  • [10] THE IN-VITRO ANTIMALARIAL ACTIVITY OF CHLORAMPHENICOL AGAINST PLASMODIUM-FALCIPARUM
    YEO, AET
    RIECKMANN, KH
    ACTA TROPICA, 1994, 56 (01) : 51 - 54
12345