In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum

被引：0
|
作者：
Khurshida Begum
Hye-Sook Kim
Veena Kumar
Igor Stojiljkovic
Yusuke Wataya
机构：
[1] Okayama University,Department of Drug Informatics, Faculty of Pharmaceutical Sciences
[2] Emory University,Department of Microbiology and Immunology
来源：
Parasitology Research | 2003年 / 90卷
关键词：
Chloroquine; Artemisinin; Antimalarial Activity; Mouse Mammary Tumor Cell; Inhibit Parasite Growth;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The in vitro antimalarial activity against Plasmodium falciparum and heme polymerization were evaluated for ten metalloporphyrins: gallium protoporphyrin IX (GaPPIX), sodium salt of gallium protoporphyrin IX, silver protoporphyrin IX, palladium protoporphyrin IX, cobalt protoporphyrin IX, manganese protoporphyrin IX, tin protoporphyrin IX (SnPPIX), chromium protoporphyrin IX, gallium deuteroporphyrin IX (GaDPIX) and gallium hematoporphyrin IX. Metalloporphyrins inhibited parasite growth with 50% inhibitory concentrations (IC50) ranging from 15.5 μM to 190 μM. In trophozoite lysate-mediated heme polymerization assays, SnPPIX, GaPPIX and GaDPIX exerted potent inhibitory activity similar to that of artemisinin and chloroquine.
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页码：221 / 224
页数：3
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