Potentiation of the antimalarial activity of atovaquone by doxycycline against Plasmodium falciparum in vitro

被引：11
|
作者：
Yeo, AET
Edstein, MD
Shanks, GD
Rieckmann, KH
机构：
[1] ARMY MALARIA RES UNIT,LIVERPOOL MIL AREA,LIVERPOOL,NSW 2174,AUSTRALIA
[2] USA,MED RES UNIT KENYA,UNIT 64109,APO,AE 09831
来源：
PARASITOLOGY RESEARCH | 1997年 / 83卷 / 05期
关键词：
D O I：
10.1007/s004360050285
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The effect of doxycycline, obtained from human volunteers administered doxycycline, on the minimum inhibitory concentration (MIC) of atovaquone was determined against the K1 and FC27 isolates of Plasmodium falciparum in vitro. Doxycycline concentrations ranging from 0.10-1.18 mu g/ml added to atovaquone produced MIC ratios [atovaquone + doxycycline/atovaquone alone] ranging from 0.38 to 0.70. These results suggest that the antimalarial activity of atovaquone is potentiated by doxycycline. Additionally, these drugs may be rational partners for the treatment and prophylaxis of falciparum malaria.
引用
收藏
页码：489 / 491
页数：3
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