Potentiation of the antimalarial activity of atovaquone by doxycycline against Plasmodium falciparum in vitro

被引：0

作者：

Anthony E. T. Yeo

Michael D. Edstein

G. Dennis Shanks

Karl H. Rieckmann

机构：

[1] Army Malaria Research Unit,

[2] Liverpool Military Area,undefined

[3] NSW 2174,undefined

[4] Australia,undefined

[5] 1653 Botany Road,undefined

[6] Banksmeadow NSW 2019,undefined

[7] Australia,undefined

[8] US Army Medical Research Unit Kenya,undefined

[9] Unit 64109,undefined

[10] Box 401,undefined

[11] APO AE 09831-4109,undefined

[12] USA,undefined

来源：

Parasitology Research | 1997年 / 83卷

关键词：

Malaria; Minimum Inhibitory Concentration; Inhibitory Concentration; Plasmodium; Doxycycline;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The effect of doxycycline, obtained from human volunteers administered doxycycline, on the minimum inhibitory concentration (MIC) of atovaquone was determined against the K1 and FC27 isolates of Plasmodium falciparum in vitro. Doxycycline concentrations ranging from 0.10-1.18 μg/ml added to atovaquone produced MIC ratios [atovaquone + doxycycline/atovaquone alone] ranging from 0.38 to 0.70. These results suggest that the antimalarial activity of atovaquone is potentiated by doxycycline. Additionally, these drugs may be rational partners for the treatment and prophylaxis of falciparum malaria.

引用

页码：489 / 491

页数：2

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