Ambiguous base pairing of 1-(2-deoxy-beta-D-ribofuranosyl) imidazole-4-carboxamide during PCR

被引：2

作者：

Pochet, S ^{[1
]}

Dugue, L ^{[1
]}

Sala, M ^{[1
]}

Pezo, V ^{[1
]}

WainHobson, S ^{[1
]}

机构：

[1] INST PASTEUR,UNITE RETROVIROL MOL,F-75724 PARIS,FRANCE

来源：

NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 7-9期

关键词：

D O I：

10.1080/07328319708006269

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of 5'-triphosphate of 1-(2-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide (dYTP) in DNA amplification reaction in place of dATP or dGTP yielded mutations frequencies of 3-4x10(-2) per base per amplification. A reasonable proportion of transversions (11-15%) was observed in the absence of deletions and insertions.

引用

页码：1749 / 1752

页数：4

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