Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture

被引：22
|
作者：
Nweke, Mauryn C. [1 ]
Rathore, Anurag S. [2 ]
Bracewell, Daniel G. [1 ]
机构：
[1] UCL, Dept Biochem Engn, Bernard Katz Bldg,Gower St, London WC1E 6BT, England
[2] IIT Delhi, Dept Chem Engn, Delhi 110016, India
来源：
TRENDS IN BIOTECHNOLOGY | 2018年 / 36卷 / 10期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1016/j.tibtech.2018.01.001
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Poor understanding of the events leading to chromatography column aging makes it difficult to monitor column lifetimes. The lack of established procedures in this area has made it difficult to establish industry standards. Therefore, it is important to understand resin aging mechanisms and techniques to monitor column aging during operation.
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页码：992 / 995
页数：5
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