Decreased levels of apolipoprotein A-I in plasma of schizophrenic patients

被引：35
|
作者：
La, Y. J.
Wan, C. L.
Zhu, H.
Yang, Y. F.
Chen, Y. S.
Pan, Y. X.
Feng, G. Y.
He, L.
机构：
[1] Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
[2] Chinese Acad Sci, Inst Nutr Sci, Shanghai, Peoples R China
来源：
JOURNAL OF NEURAL TRANSMISSION | 2007年 / 114卷 / 05期
关键词：
ApoA-I; chlorpromazine; clozapine; proteomics; schizophrenia;
D O I：
10.1007/s00702-006-0607-2
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This study aims to identify the effects of antipsychotics on plasma proteins, and on the proteins associated with schizophrenia. We applied proteomics technology to screen protein aberrations in Sprague-Dawley rats treated with antipsychotics and schizophrenic patients undergoing medication. ApoA-I was found significantly increased in the chlorpromazine-treated rats and decreased in the patients with treatment-resistant schizophrenia, which suggest that decreased levels of apoA-I might be associated with the pathology of schizophrenia and that chlorpromazine increases apoA-I levels as part of its therapeutic action.
引用
收藏
页码：657 / 663
页数：7
相关论文
共 50 条
  • [41] Identification of apolipoprotein A-I as a plasma ligand for macrophage scavenger receptor A
    Neyen, C.
    Plueddemann, A.
    Thomas, B.
    Akoulitchev, A.
    Cai, L.
    Van der Westhuyzen, D.
    Sim, R.
    Gordon, S.
    ATHEROSCLEROSIS SUPPLEMENTS, 2006, 7 (03) : 514 - 514
  • [42] Decreased functionality of A164S variant of apolipoprotein A-I in cardiovascular disease
    Petrlova, Jitka
    Dalla-Riva, Jonathan
    Lagerstedt, Jens
    FASEB JOURNAL, 2014, 28 (01):
  • [43] Apolipoprotein A-I and A-I mimetic peptides: a role in atherosclerosis
    Getz, Godfrey S.
    Reardon, Catherine A.
    JOURNAL OF INFLAMMATION RESEARCH, 2011, 4 : 83 - 92
  • [44] Apolipoprotein A-I positively associated with diabetes in women independently of apolipoprotein E genotype and apolipoprotein B levels
    Onat, Altan
    Komurcu-Bayrak, Evrim
    Can, Gunay
    Kucukdurmaz, Zekeriya
    Hergenc, Gulay
    Erginel-Unaltuna, Nihan
    NUTRITION, 2010, 26 (10) : 975 - 980
  • [45] DECREASED INTERSTITIAL APOLIPOPROTEIN-A-I LEVELS IN PATIENTS WITH DIABETIC (TYPE-I) NEPHROPATHY
    TAMSMA, JT
    BEVERDAM, FH
    LEMKES, HHPJ
    DIABETES, 1994, 43 : A201 - A201
  • [46] PLASMA APOLIPOPROTEIN CONCENTRATIONS IN FAMILIAL APOLIPOPROTEIN A-I AND A-II DEFICIENCY (TANGIER DISEASE)
    ALAUPOVIC, P
    SCHAEFER, EJ
    MCCONATHY, WJ
    FESMIRE, JD
    BREWER, HB
    METABOLISM-CLINICAL AND EXPERIMENTAL, 1981, 30 (08): : 805 - 809
  • [47] DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels
    Tlili, Asrna
    Noll, Christophe
    Middendorp, Sandrine
    Duchon, Arnaud
    Jouan, Marie
    Benabou, Eva
    Herault, Yann
    Paul, Jean-Louis
    Delabar, Jean-Maurice
    Janel, Nathalie
    MOLECULAR GENETICS AND METABOLISM, 2013, 110 (03) : 371 - 377
  • [48] THE GENETIC DETERMINATION OF PLASMA APOLIPOPROTEIN A-I LEVELS MEASURED BY RADIOIMMUNOASSAY - A STUDY OF HIGH-RISK PEDIGREES
    MOLL, PP
    SING, CF
    WILLIAMS, RR
    MAO, SJT
    KOTTKE, BA
    AMERICAN JOURNAL OF HUMAN GENETICS, 1986, 38 (03) : 361 - 372
  • [49] Apolipoprotein A-I in cerebrospinal fluid in patients with oligoclonal bands
    Facio, Maria Laura
    Garcia, Marcelo
    Alejandre, Mariel
    Borgonovo, Alida
    Burstyn, Michelle
    Barakian, Benjamin Federico
    Madalena, Leticia
    Bresciani, Pablo
    Pizzolato, Marco
    ACTA BIOQUIMICA CLINICA LATINOAMERICANA, 2023, 57 (01): : 49 - 60
  • [50] Binding of apolipoprotein A-I and acetaldehyde-modified apolipoprotein A-I to liver extracellular matrix
    Paradis, V
    Mathurin, P
    Ratziu, V
    Poynard, T
    Bedossa, P
    HEPATOLOGY, 1996, 23 (05) : 1232 - 1238
12345