Decreased levels of apolipoprotein A-I in plasma of schizophrenic patients

被引：35
|
作者：
La, Y. J.
Wan, C. L.
Zhu, H.
Yang, Y. F.
Chen, Y. S.
Pan, Y. X.
Feng, G. Y.
He, L.
机构：
[1] Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
[2] Chinese Acad Sci, Inst Nutr Sci, Shanghai, Peoples R China
来源：
JOURNAL OF NEURAL TRANSMISSION | 2007年 / 114卷 / 05期
关键词：
ApoA-I; chlorpromazine; clozapine; proteomics; schizophrenia;
D O I：
10.1007/s00702-006-0607-2
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This study aims to identify the effects of antipsychotics on plasma proteins, and on the proteins associated with schizophrenia. We applied proteomics technology to screen protein aberrations in Sprague-Dawley rats treated with antipsychotics and schizophrenic patients undergoing medication. ApoA-I was found significantly increased in the chlorpromazine-treated rats and decreased in the patients with treatment-resistant schizophrenia, which suggest that decreased levels of apoA-I might be associated with the pathology of schizophrenia and that chlorpromazine increases apoA-I levels as part of its therapeutic action.
引用
收藏
页码：657 / 663
页数：7
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