Decreased levels of apolipoprotein A-I in plasma of schizophrenic patients

被引：35
|
作者：
La, Y. J.
Wan, C. L.
Zhu, H.
Yang, Y. F.
Chen, Y. S.
Pan, Y. X.
Feng, G. Y.
He, L.
机构：
[1] Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
[2] Chinese Acad Sci, Inst Nutr Sci, Shanghai, Peoples R China
来源：
JOURNAL OF NEURAL TRANSMISSION | 2007年 / 114卷 / 05期
关键词：
ApoA-I; chlorpromazine; clozapine; proteomics; schizophrenia;
D O I：
10.1007/s00702-006-0607-2
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This study aims to identify the effects of antipsychotics on plasma proteins, and on the proteins associated with schizophrenia. We applied proteomics technology to screen protein aberrations in Sprague-Dawley rats treated with antipsychotics and schizophrenic patients undergoing medication. ApoA-I was found significantly increased in the chlorpromazine-treated rats and decreased in the patients with treatment-resistant schizophrenia, which suggest that decreased levels of apoA-I might be associated with the pathology of schizophrenia and that chlorpromazine increases apoA-I levels as part of its therapeutic action.
引用
收藏
页码：657 / 663
页数：7
相关论文
共 50 条
  • [21] APOLIPOPROTEIN A-I AND A-II LEVELS IN AN AUSTRALIAN POPULATION
    MA, X
    WEARNE, K
    LYNCH, WJ
    MASAREI, JRL
    [J]. PATHOLOGY, 1989, 21 (01) : 42 - 45
  • [22] Mild association between the A/G polymorphism in the promoter of the apolipoprotein A-I gene and apolipoprotein A-I levels: A meta-analysis
    Juo, SHH
    Wyszynski, DF
    Beaty, TH
    Huang, HY
    Bailey-Wilson, JE
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 1999, 82 (03): : 235 - 241
  • [23] Identification of apolipoprotein A-I in the α-globulin fraction of avian plasma
    Roman, Yannick
    Bed'Hom, Bertrand
    Guillot, Alain
    Levrier, Julie
    Chaste-Duvernoy, Daniel
    Bomsel-Demontoy, Marie-Claude
    Jalme, Michel Saint
    [J]. VETERINARY CLINICAL PATHOLOGY, 2009, 38 (02) : 206 - 212
  • [24] AMPHIPHILIC, HELICAL DOCOSAPEPTIDE MODEL OF PLASMA APOLIPOPROTEIN A-I
    FUKUSHIMA, D
    KUPFERBERG, JP
    YOKOYAMA, S
    KROON, DJ
    KAISER, ET
    KEZDY, FJ
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1979, (APR): : 88 - 88
  • [25] Decreased serum apolipoprotein A-I concentrations in cows infected with Salmonella Typhimurium
    Oikawa, S
    Katoh, N
    Itoh, H
    Miyamoto, T
    Konno, M
    Kajita, T
    [J]. CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE, 1997, 61 (03): : 182 - 186
  • [26] On the Aggregation of Apolipoprotein A-I
    Frankel, Rebecca
    Sparr, Emma
    Linse, Sara
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (15)
  • [27] Pharmacology of apolipoprotein A-I
    Andersson, LO
    [J]. CURRENT OPINION IN LIPIDOLOGY, 1997, 8 (04) : 225 - 228
  • [28] Apolipoprotein A-I mimetics
    Reddy, Srinivasa T.
    Navab, Mohamad
    Anantharamaiah, Gattadahalli M.
    Fogelman, Alan M.
    [J]. CURRENT OPINION IN LIPIDOLOGY, 2014, 25 (04) : 304 - 308
  • [29] Apolipoprotein A-I and Cancer
    Zamanian-Daryoush, Maryam
    DiDonato, Joseph A.
    [J]. FRONTIERS IN PHARMACOLOGY, 2015, 6
  • [30] IMMUNOELECTROPHORESIS OF APOLIPOPROTEIN A-I
    KRAJCI, A
    HROMADOVA, M
    STOZICKY, F
    [J]. PHYSIOLOGIA BOHEMOSLOVACA, 1983, 32 (06): : 531 - 531
12345