Biological influence of nanofibrous hydroxyapatite-polycaprolactone membrane on human periodontal ligament cell

被引：0

作者：

Kim, T. I. ^{[1
]}

Lee, S. J. ^{[1
]}

Ku, Y. ^{[1
]}

Rhyu, I. C. ^{[1
]}

Chung, C. P. ^{[1
]}

Han, S. B. ^{[1
]}

Kim, H. W. ^{[2
]}

机构：

[1] Seoul Natl Univ, Dent Res Inst, Seoul, South Korea

[2] Dankook Univ, Inst Tissue Regenerat Engn, Cheonan, South Korea

来源：

NSTI NANOTECH 2008, VOL 2, TECHNICAL PROCEEDINGS: LIFE SCIENCES, MEDICINE, AND BIO MATERIALS | 2008年

关键词：

hydroxyapatite; membrane; periodontal ligament fibroblast; periodontal tissue regeneration;

D O I：

暂无

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Biological effect of the hydroxyapatite-coated nanofibrous membrane was mainly investigated on the proliferation and differentiation of human periodontal ligament fibroblast. SEM revealed favorable cell attachment and spreading appearance on I day and NITS assay showed increased cell proliferation on the hydroxyapatite-coated nanofiber membrane during 14 days. From 7 to 14 days, alkaline phosphatase activity of the hydroxyapatite-coated nanofiber was significantly increased when compared to that of control group. Hydroxyapatite-coated nanofibrous membrane showed prominent mineral formation on day 14. This study revealed that the developed hydroxyapatite-coated nanofibrous membrane had favorable effects on the proliferation and differentiation of human periodontal ligament fibroblast and might be a good candidate material for periodontal tissue regeneration.

引用

页码：322 / +

页数：2

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