Biological influence of nanofibrous hydroxyapatite-polycaprolactone membrane on human periodontal ligament cell

被引:0
|
作者
Kim, T. I. [1 ]
Lee, S. J. [1 ]
Ku, Y. [1 ]
Rhyu, I. C. [1 ]
Chung, C. P. [1 ]
Han, S. B. [1 ]
Kim, H. W. [2 ]
机构
[1] Seoul Natl Univ, Dent Res Inst, Seoul, South Korea
[2] Dankook Univ, Inst Tissue Regenerat Engn, Cheonan, South Korea
来源
NSTI NANOTECH 2008, VOL 2, TECHNICAL PROCEEDINGS: LIFE SCIENCES, MEDICINE, AND BIO MATERIALS | 2008年
关键词
hydroxyapatite; membrane; periodontal ligament fibroblast; periodontal tissue regeneration;
D O I
暂无
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Biological effect of the hydroxyapatite-coated nanofibrous membrane was mainly investigated on the proliferation and differentiation of human periodontal ligament fibroblast. SEM revealed favorable cell attachment and spreading appearance on I day and NITS assay showed increased cell proliferation on the hydroxyapatite-coated nanofiber membrane during 14 days. From 7 to 14 days, alkaline phosphatase activity of the hydroxyapatite-coated nanofiber was significantly increased when compared to that of control group. Hydroxyapatite-coated nanofibrous membrane showed prominent mineral formation on day 14. This study revealed that the developed hydroxyapatite-coated nanofibrous membrane had favorable effects on the proliferation and differentiation of human periodontal ligament fibroblast and might be a good candidate material for periodontal tissue regeneration.
引用
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页码:322 / +
页数:2
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