Ultra-sensitive detection of adipocytokines with CMOS-compatible silicon nanowire arrays

Perfectly aligned arrays of single-crystalline silicon nanowires were fabricated using top-down CMOS-compatbile techniques. We demonstrates that these nanowire devices are able to detect adipocytokins secreted by adipose cells with femtomolar sensitivity, high specificity, wide detection range, and ability for parallel monitoring. The nanowire sensors also provide a novel tool to reveal the poorly understood signaling mechanisms of these newly recognized signaling molecules, as well as their relevance in common diseases such its obesity and diabetes.