The bacterial quorum sensing molecule N-(3-oxo-acyl)homoserine lactone inhibits tumor growth independent of Bcl-2 proteins

被引：0
|
作者：
Neely, Aaron M. [1 ,2 ]
Zhao, Guoping [1 ,2 ]
Schwarzer, Christian [5 ]
Lu, Huayi [6 ]
Whitt, Aaron G. [1 ,2 ]
Stivers, Nicole S. [1 ,2 ]
Burlison, Joseph A. [3 ,4 ]
Machen, Terry [5 ]
Li, Chi [1 ,2 ]
机构：
[1] Univ Louisville, Dept Pharmacol, Mol Targets Program, Louisville, KY 40292 USA
[2] Univ Louisville, Dept Toxicol, Louisville, KY 40292 USA
[3] Univ Louisville, James Graham Brown Canc Ctr, Dept Pharmacol, Struct Biol Program, Louisville, KY 40292 USA
[4] Univ Louisville, James Graham Brown Canc Ctr, Dept Toxicol, Med, Louisville, KY 40292 USA
[5] Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA
[6] Jilin Univ, Hosp 2, Changchun, Jilin, Peoples R China
来源：
FASEB JOURNAL | 2017年 / 31卷
基金：
美国国家卫生研究院;
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
823.1
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Bacterial Quorum Sensing Molecule N-3-Oxo-Dodecanoyl-L-Homoserine Lactone Causes Direct Cytotoxicity and Reduced Cell Motility in Human Pancreatic Carcinoma Cells
    Kumar, Ashwath S.
    Bryan, Jeffrey N.
    Kumar, Senthil R.
    PLOS ONE, 2014, 9 (09):
  • [22] Inter-kingdom effect on epithelial cells of the N-Acyl homoserine lactone 3-oxo-C12:2, a major quorum-sensing molecule from gut microbiota
    Landman, Cecilia
    Grill, Jean-Pierre
    Mallet, Jean-Maurice
    Marteau, Philippe
    Humbert, Lydie
    Le Balc'h, Eric
    Maubert, Marie-Anne
    Perez, Kevin
    Chaara, Wahiba
    Brot, Loic
    Beaugerie, Laurent
    Sokol, Harry
    Thenet, Sophie
    Rainteau, Dominique
    Seksik, Philippe
    Quevrain, Elodie
    PLOS ONE, 2018, 13 (08):
  • [23] Paraoxonase 2 Mediates Metabolic Reprogramming of Murine Tracheal Epithelial Cells in Response to the Quorum Sensing Molecule N-(3-oxododecanoyl)-homoserine Lactone
    Whitt, Aaron
    Jiu-Zhen, Jin
    Burlison, Joseph
    Hill, Bradford
    White, Carl
    Li, Chi
    FASEB JOURNAL, 2021, 35
  • [24] The Pseudomonas aeruginosa quorum-sensing signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone, inhibits porcine arterial smooth muscle contraction
    Lawrence, RN
    Dunn, WR
    Bycroft, B
    Camara, M
    Chhabra, SR
    Williams, P
    Wilson, VG
    BRITISH JOURNAL OF PHARMACOLOGY, 1999, 128 (04) : 845 - 848
  • [25] Novel Paraoxonase 2-Dependent Mechanism Mediating the Biological Effects of the Pseudomonas aeruginosa Quorum-Sensing Molecule N-(3-Oxo-Dodecanoyl)-L-Homoserine Lactone
    Horke, Sven
    Xiao, Junhui
    Schuetz, Eva-Maria
    Kramer, Gerald L.
    Wilgenbus, Petra
    Witte, Ines
    Selbach, Moritz
    Teiber, John F.
    INFECTION AND IMMUNITY, 2015, 83 (09) : 3369 - 3380
  • [26] The intestinal quorum sensing 3-oxo-C12:2 Acyl homoserine lactone limits cytokine-induced tight junction disruption
    Aguanno, Doriane
    Coquant, Garance
    Postal, Barbara G.
    Osinski, Celine
    Wieckowski, Margaux
    Stockholm, Daniel
    Grill, Jean-Pierre
    Carriere, Veronique
    Seksik, Philippe
    Thenet, Sophie
    TISSUE BARRIERS, 2020, 8 (04):
  • [27] The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-1-homoserine lactone has immunomodulatory activity
    Telford, G
    Wheeler, D
    Williams, P
    Tomkins, PT
    Appleby, P
    Sewell, H
    Stewart, GSAB
    Bycroft, BW
    Pritchard, DI
    INFECTION AND IMMUNITY, 1998, 66 (01) : 36 - 42
  • [28] Modification of cell vulnerability to oxidative stress by N-(3-oxododecanoyl)-L-homoserine-lactone, a quorum sensing molecule, in rat thymocytes
    Nishimura-Danjobara, Yumiko
    Oyama, Keisuke
    Oyama, Tomohiro M.
    Yokoigawa, Kumio
    Oyama, Yasuo
    CHEMICO-BIOLOGICAL INTERACTIONS, 2019, 302 : 143 - 148
  • [29] Pseudomonas aeruginosa quorum sensing molecule N-(3 oxododecanoyl)-L-homoserine lactone disrupts epithelial barrier integrity of Caco-2 cells
    Vikstrom, Elena
    Tafazoli, Farideh
    Magnusson, Karl-Eric
    FEBS LETTERS, 2006, 580 (30) : 6921 - 6928
  • [30] Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxo-dodecanoyl)-l-homoserine lactone triggers mitochondrial dysfunction and apoptosis in neutrophils through calcium signaling
    Pradeep Kumar Singh
    Vivek Kumar Yadav
    Manmohit Kalia
    Deepmala Sharma
    Deepak Pandey
    Vishnu Agarwal
    Medical Microbiology and Immunology, 2019, 208 : 855 - 868
12345