Poly(ester-anhydride) for controlled delivery of hydrophilic drugs

被引：7
|
作者：
Ickowicz, Diana E. [1 ]
Abtew, Ester [1 ]
Khan, Wahid [1 ,2 ]
Golovanevski, Ludmila [3 ]
Steinman, Noam [1 ]
Weiniger, Carolyn F. [3 ,4 ]
Domb, Abraham J. [1 ]
机构：
[1] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Inst Drug Res, IL-91120 Jerusalem, Israel
[2] NIPER, Dept Pharmaceut, Hyderabad, Andhra Pradesh, India
[3] Hadassah Hebrew Univ, Med Ctr, Dept Anesthesiol & Crit Care Med, Jerusalem, Israel
[4] Stanford Sch Med, Stanford, CA USA
来源：
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2016年 / 31卷 / 02期
基金：
以色列科学基金会;
关键词：
Drug delivery; gentamicin; ricinoleic acid; poly(ester-anhydride); sebacic acid; thyrotropin-releasing hormone; ACID) BIODEGRADABLE CARRIER; IN-VITRO RELEASE; RICINOLEIC ACID; DEGRADATION; PACLITAXEL; POLYANHYDRIDES; ELIMINATION; GENTAMICIN;
D O I：
10.1177/0883911515598796
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Injectable pasty polyester-anhydride based on sebacic acid and ricinoleic acid at a 30:70w/w ratio, poly(sebacic-co-ricinoleic-ester-anhydride) 3:7, was synthesized from the esterification of ricinoleic acid on poly(sebacic acid) followed by polyanhydride condensation. The effect of castor oil, citric acid, and glycerol added at 1% w/w as branching agents was determined. Castor oil and citric acid increased the viscosity, while glycerol decreased the viscosity of the polymer. Constant release of gentamicin and thyrotropin-releasing hormone incorporated in the polymer paste was monitored during 28days.
引用
收藏
页码：127 / 139
页数：13
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