Synthesis, characterization, and degradation of poly(ester-anhydride) for particulate delivery

被引：5
|
作者：
Modi, S [1 ]
Jain, JP [1 ]
Kumar, N [1 ]
机构：
[1] Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut, Mohali 160062, India
来源：
ISRAEL JOURNAL OF CHEMISTRY | 2005年 / 45卷 / 04期
关键词：
D O I：
10.1560/0M15-CNAQ-BDR7-XFCM
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of poly(ester-anhydride) from poly(lactic acid) and poly(sebacic acid) have been synthesized and characterized. Poly(lactic acid) of molecular weight 2,550 Da has been synthesized from pharmaceutical grade lactic acid. The copolymers are in the molecular weight range of 3,000-15,000 Da, with the higher molecular weights obtained for the polymers with higher sebacic acid content. With increase in sebacic acid content, the melting point is also found to increase. The polymers with 50% or more poly(sebacic acid) content melt between 80 and 84 degrees C. These polymers have been formulated into microspheres and their degradation studied. Due to their biodegradability and the flexibility to alter their degradation profile, they find a wide application in drug delivery.
引用
收藏
页码：401 / 409
页数：9
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