Alternating Poly(ester-anhydride) by Insertion Polycondensation

被引：13

作者：

Haim-Zada, Moran ^{[1
]}

Basu, Arijit ^{[1
]}

Hagigit, Tal ^{[2
]}

Schlinger, Ron ^{[2
]}

Grishko, Michael ^{[3
]}

Kraminsky, Alexander ^{[3
]}

Hanuka, Ezra ^{[3
]}

Domb, Abraham J. ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Drug Res, Sch Pharm, IL-9112001 Jerusalem, Israel

[2] Dexcel Pharma Technol Ltd, IL-30600000 Or Akiva, Israel

[3] TAMI Inst Res & Dev Ltd, IL-26111 Haifa, Israel

来源：

BIOMACROMOLECULES | 2016年 / 17卷 / 06期

关键词：

ACID) BIODEGRADABLE CARRIER; RICINOLEIC ACID; CASTOR-OIL; POLYANHYDRIDES; POLY(EPSILON-CAPROLACTONE); POLYESTERS; PRECURSORS; PACLITAXEL; RELEASE;

D O I：

10.1021/acs.biomac.6b00523

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report on a synthetic method where polyanhydride is used as starting material and the ester monomers are inserted through complete esterification, leading to ail alternating ester-anhydride copolymer. The molar ratio of ricinoleic add.(RA) and sebacic acid (SA) was optimized until- polysebacic acid is completely converted to carboxylic acid-terminated RA-SA and RA-SA-RA ester-dicarboxylic acids. These, dimers and trimers were activated with acetic anhydride, polymerized. under heat and vacuum to yield alternating RA-SA- copolymer. The fesulting alternating poly(ester-anhydride) have the RA at regular intervals. The regular occurrences Of RA side chains prevent anhydride interchange, enhancing hydrolytic stability, which allows storage of the polymer at room temperature.

引用

页码：2253 / 2259

页数：7

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