Poly(ester-anhydride) for controlled delivery of hydrophilic drugs

被引：7

作者：

Ickowicz, Diana E. ^{[1
]}

Abtew, Ester ^{[1
]}

Khan, Wahid ^{[1
,2
]}

Golovanevski, Ludmila ^{[3
]}

Steinman, Noam ^{[1
]}

Weiniger, Carolyn F. ^{[3
,4
]}

Domb, Abraham J. ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Inst Drug Res, IL-91120 Jerusalem, Israel

[2] NIPER, Dept Pharmaceut, Hyderabad, Andhra Pradesh, India

[3] Hadassah Hebrew Univ, Med Ctr, Dept Anesthesiol & Crit Care Med, Jerusalem, Israel

[4] Stanford Sch Med, Stanford, CA USA

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2016年 / 31卷 / 02期

基金：

以色列科学基金会;

关键词：

Drug delivery; gentamicin; ricinoleic acid; poly(ester-anhydride); sebacic acid; thyrotropin-releasing hormone; ACID) BIODEGRADABLE CARRIER; IN-VITRO RELEASE; RICINOLEIC ACID; DEGRADATION; PACLITAXEL; POLYANHYDRIDES; ELIMINATION; GENTAMICIN;

D O I：

10.1177/0883911515598796

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Injectable pasty polyester-anhydride based on sebacic acid and ricinoleic acid at a 30:70w/w ratio, poly(sebacic-co-ricinoleic-ester-anhydride) 3:7, was synthesized from the esterification of ricinoleic acid on poly(sebacic acid) followed by polyanhydride condensation. The effect of castor oil, citric acid, and glycerol added at 1% w/w as branching agents was determined. Castor oil and citric acid increased the viscosity, while glycerol decreased the viscosity of the polymer. Constant release of gentamicin and thyrotropin-releasing hormone incorporated in the polymer paste was monitored during 28days.

引用

页码：127 / 139

页数：13

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