Synthesis of Multisubstituted Guanidines through Palladium-Catalyzed Insertion of Isonitriles

被引：5
|
作者：
Li, Pei-Xia [1 ]
Meng, Xiu-Jin [1 ]
Yang, Li [2 ]
Tang, Hai-Tao [1 ]
Pan, Ying-Ming [1 ]
机构：
[1] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China
[2] Guangxi Zhuang Autonomous Region Forestry Res Ins, Guangxi Key Lab Special Nonwood Forest Cultivat &, Nanning 530002, Peoples R China
来源：
SYNLETT | 2018年 / 29卷 / 17期
关键词：
insertion of isonitriles; unactivated amides; cascade transformation; palladium; ISOCYANIDE INSERTION; ANALOGS;
D O I：
10.1055/s-0037-1610981
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new method for the synthesis of multisubstituted guanidines through tandem intermolecular insertion of isonitriles with unactivated amides has been developed. In this study, isonitriles could be used not only as reaction materials but also as the source of amines.
引用
收藏
页码：2326 / 2330
页数：5
相关论文
共 50 条
  • [41] Carbonylative Synthesis of Thiochromenones via Palladium-Catalyzed tert -Butyl Isocyanide Insertion
    Zhang, Fang-Ling
    Chen, Zhen-Bang
    Liu, Kui
    Yuan, Qing
    Jiang, Qing
    Zhu, Yong-Ming
    SYNLETT, 2018, 29 (05) : 621 - 626
  • [42] Palladium-Catalyzed Synthesis of Amidines via tert-Butyl isocyanide Insertion
    Palinkas, Noemi
    Kollar, Laszlo
    Kegl, Tamas
    ACS OMEGA, 2018, 3 (11): : 16118 - 16126
  • [43] SYNTHESIS OF ALLYLIC AMINES THROUGH THE PALLADIUM-CATALYZED HYDROAMINATION OF ALLENES
    BESSON, L
    GORE, J
    GAZES, B
    TETRAHEDRON LETTERS, 1995, 36 (22) : 3857 - 3860
  • [44] Total Synthesis of Linoxepin through a Palladium-Catalyzed Domino Reaction
    Tietze, Lutz F.
    Duefert, Svenia-C.
    Clerc, Jerome
    Bischoff, Matthias
    Maass, Christian
    Stalke, Dietmar
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (11) : 3191 - 3194
  • [45] New synthesis of donepezil through palladium-catalyzed hydrogenation approach
    Elati, CR
    Kolla, N
    Chalamala, SR
    Vankawala, PJ
    Sundaram, V
    Vurimidi, H
    Mathad, VT
    SYNTHETIC COMMUNICATIONS, 2006, 36 (02) : 169 - 174
  • [46] Palladium-Catalyzed Synthesis of 5-Iminopyrrolones through Isocyanide Double Insertion Reaction with Terminal Alkynes and Water
    He, Yan
    Wang, Ying-Chun
    Hu, Kun
    Xu, Xiao-Ling
    Wang, Heng-Shan
    Pan, Ying-Ming
    JOURNAL OF ORGANIC CHEMISTRY, 2016, 81 (23): : 11813 - 11818
  • [47] Synthesis of 2,3-Difunctionalized Benzofuran Derivatives through Palladium-Catalyzed Double Isocyanide Insertion Reaction
    Hu, Weigao
    Li, Meng
    Jiang, Guangbin
    Wu, Wanqing
    Jiang, Huanfeng
    ORGANIC LETTERS, 2018, 20 (12) : 3500 - 3503
  • [48] Palladium-catalyzed double N-arylation to synthesize multisubstituted dibenzoazepine derivatives
    Zhang, Xiaoyun
    Yang, Yuan
    Liang, Yun
    TETRAHEDRON LETTERS, 2012, 53 (47) : 6406 - 6408
  • [49] Palladium-catalyzed condensation of N -aryl imines and alkynylbenziodoxolones to form multisubstituted furans
    Yoshikai, N. (nyoshikai@ntu.edu.sg), 1600, American Chemical Society (136):
  • [50] Palladium-Catalyzed Carbonylation/Acyl Migratory Insertion Sequence
    Zhang, Zhenhua
    Liu, Yiyang
    Gong, Mingxing
    Zhao, Xiaokun
    Zhang, Yan
    Wang, Jianbo
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (06) : 1139 - 1142
12345