Total Synthesis of Linoxepin through a Palladium-Catalyzed Domino Reaction

被引：46
|
作者：
Tietze, Lutz F. [1 ]
Duefert, Svenia-C. [1 ]
Clerc, Jerome [1 ]
Bischoff, Matthias [1 ]
Maass, Christian [2 ]
Stalke, Dietmar [2 ]
机构：
[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany
[2] Univ Gottingen, Inst Anorgan Chem, D-37077 Gottingen, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 11期
关键词：
domino reactions; lignans; palladium; structure elucidation; total synthesis; TETRASUBSTITUTED ALKENES; EFFICIENT SYNTHESIS; CASCADE REACTIONS; NATURAL-PRODUCTS; HECK REACTION; H-ACTIVATION; C-C; CYCLIZATION; CARBONYLATION; HETEROCYCLES;
D O I：
10.1002/anie.201209868
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Convergent and elegant: Linoxepin (see picture), a new lignan with an unusual oxepin moiety, has been synthesized in only 10 steps. The protecting-group-free total synthesis includes a palladium- catalyzed Sonogashira reaction and a domino carbopalladation/Heck reaction of an allylsilane. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：3191 / 3194
页数：4
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