Synthesis of 1H-Thiopyrano[4,3-c]quinoline Scaffold via One-pot Three-component Cyclization

被引：8

作者：

Alizadeh, Abdolali ^{[1
]}

Rezaiyehraad, Reza ^{[1
]}

Roosta, Atefeh ^{[1
]}

Halvagar, Mohammad Reza ^{[2
]}

机构：

[1] Tarbiat Modares Univ, Dept Chem, POB 14115-175, Tehran, Iran

[2] CCERCI, Pajohesh Blvd,17th Km Tehran Karaj Highway, Tehran 1496813151, Iran

来源：

CHEMISTRYSELECT | 2019年 / 4卷 / 41期

关键词：

2-chloroquinoline-3-carbaldehyde; phenacyl thiocyanate; 1H-thiopyrano[4; 3-c]quinoline; thiopyranoquinoline; EFFICIENT ONE-POT; MICROWAVE-ASSISTED SYNTHESIS; DOMINO REACTIONS; HETEROCYCLIC-ANALOGS; ANTITUMOR-ACTIVITY; DNA-BINDING; DERIVATIVES; CONSTRUCTION; QUINOLINES; FACILE;

D O I：

10.1002/slct.201903019

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convenient and effective one-pot synthetic method for functionalized 1H-thiopyrano[4,3-c]quinoline scaffold via three-component cyclization is described. This procedure contains the reaction between 2-chloroquinoline-3-carbaldehyde and 2 equivalents of phenacyl thiocyanate in the presence of triethylamine in absolute ethanol at room temperature with good yield. This eco-friendly method has advantages such as reduction of waste, short synthetic procedure, and little amount of required reagents.

引用

页码：12049 / 12052

页数：4

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