Synthesis of 1H-Thiopyrano[4,3-c]quinoline Scaffold via One-pot Three-component Cyclization

被引：8
|
作者：
Alizadeh, Abdolali [1 ]
Rezaiyehraad, Reza [1 ]
Roosta, Atefeh [1 ]
Halvagar, Mohammad Reza [2 ]
机构：
[1] Tarbiat Modares Univ, Dept Chem, POB 14115-175, Tehran, Iran
[2] CCERCI, Pajohesh Blvd,17th Km Tehran Karaj Highway, Tehran 1496813151, Iran
来源：
CHEMISTRYSELECT | 2019年 / 4卷 / 41期
关键词：
2-chloroquinoline-3-carbaldehyde; phenacyl thiocyanate; 1H-thiopyrano[4; 3-c]quinoline; thiopyranoquinoline; EFFICIENT ONE-POT; MICROWAVE-ASSISTED SYNTHESIS; DOMINO REACTIONS; HETEROCYCLIC-ANALOGS; ANTITUMOR-ACTIVITY; DNA-BINDING; DERIVATIVES; CONSTRUCTION; QUINOLINES; FACILE;
D O I：
10.1002/slct.201903019
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A convenient and effective one-pot synthetic method for functionalized 1H-thiopyrano[4,3-c]quinoline scaffold via three-component cyclization is described. This procedure contains the reaction between 2-chloroquinoline-3-carbaldehyde and 2 equivalents of phenacyl thiocyanate in the presence of triethylamine in absolute ethanol at room temperature with good yield. This eco-friendly method has advantages such as reduction of waste, short synthetic procedure, and little amount of required reagents.
引用
收藏
页码：12049 / 12052
页数：4
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