One-pot synthesis of quinoline-based tetracycles by a tandem three-component reaction

被引：57
|
作者：
Che, Chao
Xiang, Jing
Wang, Guo-Xin
Fathi, Reza
Quan, Jun-Min
Yang, Zhen [1 ]
机构：
[1] Peking Univ, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Shenzhen Grad Sch,Lab Chem Genom, Beijing 100871, Peoples R China
[2] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Coll Chem,BNLMS, Beijing 100871, Peoples R China
[3] XTL Biopharmaceut Inc, New York, NY 10989 USA
来源：
JOURNAL OF COMBINATORIAL CHEMISTRY | 2007年 / 9卷 / 06期
关键词：
D O I：
10.1021/cc070058a
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A practical one-pot synthetic strategy for the efficient synthesis of a range of structurally interesting and bioactive quinoline-based tetracycles has been developed. A key step in the synthesis is a tandem three-component reaction of heteroaromatic amine, methyl 2-formylbenzoate and (t)butyl isonitrile, followed by TFA-mediated lactamization via intramolecular aminolysis of an adjacent ester. Results related to a kinase-panel screening for several selected compounds are also discussed in this article.
引用
收藏
页码：982 / 989
页数：8
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