One-pot synthesis of quinoline-based tetracycles by a tandem three-component reaction

被引：57

作者：

Che, Chao

Xiang, Jing

Wang, Guo-Xin

Fathi, Reza

Quan, Jun-Min

Yang, Zhen ^{[1
]}

机构：

[1] Peking Univ, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Shenzhen Grad Sch,Lab Chem Genom, Beijing 100871, Peoples R China

[2] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Coll Chem,BNLMS, Beijing 100871, Peoples R China

[3] XTL Biopharmaceut Inc, New York, NY 10989 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2007年 / 9卷 / 06期

关键词：

D O I：

10.1021/cc070058a

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A practical one-pot synthetic strategy for the efficient synthesis of a range of structurally interesting and bioactive quinoline-based tetracycles has been developed. A key step in the synthesis is a tandem three-component reaction of heteroaromatic amine, methyl 2-formylbenzoate and (t)butyl isonitrile, followed by TFA-mediated lactamization via intramolecular aminolysis of an adjacent ester. Results related to a kinase-panel screening for several selected compounds are also discussed in this article.

引用

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页码：982 / 989

页数：8

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