Three-component one-pot synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives in aqueous media

被引：97
|
作者：
Shi, DQ [1 ]
Jie, M
Zhuang, QY
Niu, LH
Wu, N
Wang, XS
机构：
[1] Xuzhou Normal Univ, Dept Chem, Xuzhou 221116, Peoples R China
[2] Key Lab Biotechnol Med Plant Jiangsu Prov, Xuzhou 221116, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 24期
关键词：
aqueous media; 1,4-dihydropyrano[2,3-c]pyrazoles; one-pot synthesis; three component;
D O I：
10.1081/SCC-200043224
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
6-Amino-5-cyano-4-aryl-1,4-dihydropyrano[2,3-c]pyrazoles were synthesized by three-component reaction of aromatic aldehydes, malononitrile, and 3-methyl-1-phenyl-2-pyrazolin-5-one using triethylbenzylammonium chloride (TEBA) as catalyst in aqueous media. The reaction has the advantages of good yield, less pollution, ease of separation, and of being environment friendly.
引用
收藏
页码：4557 / 4563
页数：7
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